Parp Inhibitor Ovarian Cancer Side Effects

Here two oncology pharmacists discuss the side effects of parp inhibitor treatment and how to prevent and treat nausea and vomiting in this patient population.

Parp inhibitor ovarian cancer side effects.

We spoke to dr. Introduction poly adp ribose polymerase parp inhibitors are a class of oral anticancer medications that have the most evidence for use in patients with inherited germline mutations. Yet investigators state the drug is well tolerated. Parp inhibitors are an effective and promising treatment for ovarian cancers but they still bring with them the risk of some side effects you should discuss with your doctor.

Nausea was common affecting 76 of. The race is on js brown and others british journal of cancer 2016. Several forms of cancer are more dependent on parp than regular cells making parp parp1 parp2 etc an attractive target for cancer therapy parp inhibitors appear to improve progression free. Volume 3 issue 3.

11 of patients on the parp inhibitor discontinued treatment due to side effects. Maintenance therapy with angiogenesis inhibitors and parp inhibitors has been shown to extend the time between the completion of chemotherapy and the relapse of ovarian cancer. Fatigue is a common side effect and is reported with all three parp inhibitors 3 11 14 when a patient receiving a parp inhibitor complains of fatigue it is important to rule out other contributing factors such as disease related fatigue depression insomnia and anemia as well as sedation from concomitant medications. Parp inhibitors which work by preventing bad acting cancer cells from repairing their own dna and continuing to spread have shown tremendous promise in treating women with ovarian cancer the pool of women for whom parp inhibitors are an option has expanded widely in recent years to the point in which almost all women with ovarian cancer are candidates to receive the drugs at some point.

Findings from the prima trial were published september 28 in the new england journal of medicine. A phase i ii study of the oral parp inhibitor rucaparib in patients with germline brca1 2 mutated ovarian carcinoma or other solid tumors. Parp inhibitors in ovarian cancer. Parp inhibitors are a group of pharmacological inhibitors of the enzyme poly adp ribose polymerase parp.

New treatment option for ovarian cancer. Parp inhibitors rs meehan and ap chen gynecologic oncology research and practice 2016. Evidence experience and clinical potential t evans and u. Ursula matulonis chief of gynecologic oncology at the dana farber cancer institute to learn more about these potential side effects.

They are developed for multiple indications including the treatment of heritable cancers. Clin cancer res 2017 23 15 4095 4106.